Endocrine Abstracts

Background: The metabolic syndrome (MetS) is a combination of unfavourable health factors including abdominal obesity, dyslipidaemia, hypertension and impaired fasting glucose. Several small-scale studies have reported a relationship between thyroid function and some MetS components or suggested that serum FT3 levels within the normal range were independently associated with insulin resistance. We assessed how thyroid function relates to the prevalence of MetS in a large popul...

Background: Early diagnosis and treatment of high blood pressure (BP) and high cholesterol is important to reduce cardiovascular mortality risk.Methods: We assessed actual BP and LDL-cholesterol (LDL-C) levels in 88,029 participants (36,122 men), aged 18-80 yrs, without diabetes, from the Dutch Lifelines Cohort study. Participants were categorized according to degree of obesity (normal weight, overweight, obese) and age decade group. BP measurement was r...

Aim: We assessed in both men and women within different BMI- and age classes the prevalence of MetS and its individual components, since these specific estimates obtained simultaneously in a large western European population are lacking. Secondly, we measured as well how age-specific blood pressure (BP) cut-offs affect the prevalence of elevated BP and MetS.Methods: Data of 74 531 western European participants, aged 18–79 years, were obtained from t...

Introduction: The metabolic syndrome (MetS) is a strong predictor of cardiovascular risk. It is influenced by environmental factors, and its prevalence is high in subjects with obesity.Design: We assessed differences in glucose- and lipid parameters, and hsCRP and microalbuminuria (MA) in obese subjects with and without metabolic syndrome (MetS) in LifeLines, a population-based study. Included were subjects 18–80 years, with BMI>30 kg/m2</s...

Introduction: Obesity is increasingly prevalent in Western society. In addition to medical consequences, obesity also affects health-related quality of life (HR-QOL).Design: We assessed the differences in HR-QOL in obese participants with and without metabolic syndrome (MetS), by level of obesity and level of inflammation, in the LifeLines Cohort study, a population-based study. In total, 12 765 subjects age 18–80 years, with BMI >30 kg/m2<...

Background: The clustering of metabolic and cardiovascular risk factors is known as the metabolic syndrome (MetS). Lifestyle factors like smoking may contribute to the differences in prevalence of the MetS. The aim of this study was to examine the association between smoking and the MetS and its components in different BMI classes.Methods: The present cross-sectional evaluation comprised 24 762 men and 35 558 women, participating in the LifeLines Cohort ...

Background: Skin autofluorescence (SAF) has been demonstrated to be associated with long-term cardiovascular complications in subjects with either diabetes or renal failure. Since the metabolic syndrome (MetS) is a risk factor for cardiovascular disease, the aim of the study was to assess the association between SAF and MetS as well as its individuals components.Materials and methods: For this cross-sectional analysis, we included subjects 18–80 yea...

Introduction: Despite adequate treatment with LT4 monotherapy, many patients with primary hypothyroidism still report complaints, as this treatment can not exactly imitate the endogenous homeostasis. We examined whether the different domains of HR-QOL were affected by the existence of a thyroid disorder and use of LT4 substitution, and whether a lower ratio of free triiodothyronine (fT3)–free thyroxine (fT4)</sup...

Background: Skin autofluorescence (SAF), measured with the AGE-reader, predicts cardiovascular disease (CVD) and type 2 diabetes (T2D). Thyroid hormone levels (TH) may affect this association. In the present study, we examined whether TH predict 4-years risk of T2D, CVD and mortality in the general population independently of SAF.Methods: We included 28245 participants (age 44±12 years, BMI 25.9±4.3 kg/m2) of the Dutch Lifelines Coho...

Background: The metabolic syndrome (MetS) is a combination of unfavourable health factors including visceral obesity, dyslipidaemia, hypertension and impaired fasting glucose. It is also strongly associated with increased risk of cardiovascular disease (CVD) and type 2 diabetes. We assessed which factors contribute to the prevalence of MetS in people within different weight and age categories.Methods: 64 046 western European participants aged 18–80 ...